Spider-Man: Reign is in my opinion one of the more underrated Spidey stories out there. There's a bit of a "all there is to know about 'The Crying Game'" twist that's overshadowed the rest of the story. It's also been derided as a knock off The Dark Knight Returns (and the similarities are acknowledged with a character called 'Miller Janson') but in my opinion all they have in common is the concept of an aging superhero being called out of retirement. Simply put, Spider-Man and Batman are two very different characters -- you're not going to see Spider-Man as a hardened vigilante beating the crap out of Captain America. They're also products of two different periods; TDKR takes place during the Cold War, while Reign (although the connection is not as explicit) draws parallels with a post-9/11 America.
( Scans under the cut... )