From Brian K. Vaughan's Y: The Last Man, in which there are more than a few awesome female characters, there's Agent 355. Introduced as the bodyguard of Yorick, the last male left alive on the planet, she soon became one of the central characters of the series.
( Oh, yes - BAMF. )
This year, another fun moment! (well for me at least) in the Yorick/355 interaction.
Many of their conversations in general qualify as "perfect moment", but this one is #2 on the fav list!
( it was the Beatles reference that sealed the deal )
next year: the scene in that last issue that makes everyone cry like a bitch! (great scene tho. Read the series just for that if nothing else)
Y: The Last Man is one of my favorite series of all time. It's an amazing coming-of-age story that is alternatively hilarious, exhilarating, thought-provoking, and ultimately, heart-wrenching, but never ceases to be entertaining. Do yourself a favor and check it out!