Actually, I'd think the Red Skull would be a good role to cast someone in if you DID want to use him again. I mean, the whole deal with the Skull is that he's either constantly wearing a skull-mask, or his face genuinely looks like a red skull, depending on what's currently the case. Either way, you almost never see his actual face, and if they're going with the 'deformed skull-face' version, they could easily use him in something else - it's not like he'd be easily recognizable as himself with the makeup on.
I recommend 'Streets of Fire'. It's a cult film, so you'll either love it or hate it, but I'm certainly in the former category, and while Dafoe doesn't have a hugely visible part in it, he makes the most of what screen time he's got. (He also wears a pair of overalls that are a sight to behold - as one website reviewer put it, they 'appear to be made of trash bags', although they're probably leather or something. Either way, they make for a memorable visual.)