Honestly, they're both on the list of characters whose powers and abilities would be pretty scary if they weren't in the hands of unimaginative dorks.

The Spot's covered in a few hundred short-range interdimensional teleport gates and Slyde invented a virtually frictionless, reactionless material. Either of them could be made into killing machines with a little work.

Now that I think about it, the Hand's resurrection trick is basically an in-universe gritty reboot.