He's got a much bigger part in the show, so they made him more relatable and sympathetic. I think it was a good choice, because in the comic he's literally the butt of a thousand jokes. In the show, he's a genuinely nice kid who keeps getting shit on by fate.

In that clip you see Preacher saying Eugene has no right to condemn him for being a sinner... but we've since seen what really happened at the shooting, and you realize Eugene is a tragic victim.

Who now has Hitler as a cellmate.