In 2004 Marvel released a Spider-Man title under the 'Marvel Knights' imprint. The basic idea was to make a more "hard PG-13" Spider-Man title with Mark Millar and Terry Dodson delivering a 12 issue arc in three parts. There's no official title for the whole thing but it's been called "Shush" by the fans given the obvious similarities to 'Hush' that was running around the same time; an "epic" about a mystery villain causing havoc that happens to involve the majority of the hero's rogue gallery.
FWIW, while both are a lot of 'style over substance', I enjoyed "Shush" a lot more. You may think differently.
Spectacular Spider-Man #197, 198 and the first few pages of #199 are a team-up of Spider-Man and the original X-Men. Some time ago, Professor Aaron Power wanted Charles Xavier to restore his son, Matthew. Things did not go well.
( Jean Grey and her telepathic ethics )
The second back up story is a six page "Saga of the Serpent Crown" story where the Celestials almost but not quite end the world.
( Three pages after the cut )
Since S_D seems to be on an Ennis kick atm I figured I'd repost an entry I did a while back for his Spider-Man story 'The Thousand' which was part of the 'Tangled Web' anthology book.
While it's more SFW than your average Ennis book, there is quite a bit of gruesome body horror that wouldn't be out of place in a Cronenberg film, so take that as a warning.
( Scans under the cut... )